Journal article
Gross anatomical features of the insular cortex in affective disorders
T Takahashi, D Sasabayashi, M Yücel, S Whittle, M Suzuki, C Pantelis, GS Malhi, NB Allen
Frontiers in Psychiatry | FRONTIERS MEDIA SA | Published : 2024
Abstract
Introduction: The number of insular gyri is elevated in patients with schizophrenia. Thus, it has potential as a marker of early neurodevelopmental abnormalities. However, currently it remains unclear whether patients with other neuropsychiatric disorders, such as affective disorders, also have this gross brain anatomical feature. Materials and methods: The macroscopic features of the insular cortex in 26 patients with bipolar disorder (BD), 56 with major depressive disorder (MDD), and control subjects for each clinical group (24 for BD and 33 for MDD) were assessed using magnetic resonance imaging. Results: The number of short insular gyri was higher in BD patients than in matched controls ..
View full abstractRelated Projects (1)
Grants
Awarded by Japan Agency for Medical Research and Development
Funding Acknowledgements
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported in part by JSPS KAKENHI Grant Number No. 24K10704 to TT, JP22K15745 to DS, and JP20H03598 to MS, and by the Japan Agency for Medical Research and Development (AMED) Grant Number JP24wm0625302 to TT. CP was supported by a National Health and Medical Research Council (NHMRC) L3 Investigator Grant (1196508) and a NHMRC Program Grant (ID: 1150083). The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report.